| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50167086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1573537 (CHEMBL3801492) |
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| IC50 | 101±n/a nM |
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| Citation |  Zhao, Z; Harrison, ST; Schubert, JW; Sanders, JM; Polsky-Fisher, S; Zhang, NR; McLoughlin, D; Gibson, CR; Robinson, RG; Sachs, NA; Kandebo, M; Yao, L; Smith, SM; Hutson, PH; Wolkenberg, SE; Barrow, JC Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors. Bioorg Med Chem Lett26:2952-2956 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | LSS_RAT | Lss | Osc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83302.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12083 |
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| Residue: | 733 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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| BDBM50167086 |
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| n/a |
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| Name | BDBM50167086 |
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| Synonyms: | CHEMBL3798212 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3O2S |
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| Mol. Mass. | 327.401 |
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| SMILES | CC(C)(C)c1nc(cs1)-c1ccnc(c1)-n1ccc(=O)c(O)c1 |
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| Structure | 
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