Reaction Details |
| Report a problem with these data |
Target | Rhodopsin kinase GRK1 |
---|
Ligand | BDBM50173310 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1581284 (CHEMBL3811361) |
---|
IC50 | 3900±n/a nM |
---|
Citation | Waldschmidt, HV; Homan, KT; Cruz-Rodríguez, O; Cato, MC; Waninger-Saroni, J; Larimore, KM; Cannavo, A; Song, J; Cheung, JY; Kirchhoff, PD; Koch, WJ; Tesmer, JJ; Larsen, SD Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem59:3793-807 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Rhodopsin kinase GRK1 |
---|
Name: | Rhodopsin kinase GRK1 |
Synonyms: | G protein-coupled receptor kinase 1 | GRK1 | GRK1_HUMAN | PK | RHOK | Rhodopsin kinase |
Type: | PROTEIN |
Mol. Mass.: | 63520.09 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774378 |
Residue: | 563 |
Sequence: | MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES
VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK
LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL
EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK
ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ
IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA
PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS
QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY
AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM
PDDMKGISGGSSSSSKSGMCLVS
|
|
|
BDBM50173310 |
---|
n/a |
---|
Name | BDBM50173310 |
Synonyms: | CHEMBL3808660 | US10023564, Example 1 |
Type | Small organic molecule |
Emp. Form. | C26H22FN7O3 |
Mol. Mass. | 499.4964 |
SMILES | CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| |
Structure |
|