Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase pim-1 |
---|
Ligand | BDBM50174157 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1581410 (CHEMBL3812017) |
---|
IC50 | 0.400000±n/a nM |
---|
Citation | Cee, VJ; Chavez, F; Herberich, B; Lanman, BA; Pettus, LH; Reed, AB; Wu, B; Wurz, RP; Andrews, KL; Chen, J; Hickman, D; Laszlo, J; Lee, MR; Guerrero, N; Mattson, BK; Nguyen, Y; Mohr, C; Rex, K; Sastri, CE; Wang, P; Wu, Q; Wu, T; Xu, Y; Zhou, Y; Winston, JT; Lipford, JR; Tasker, AS; Wang, HL Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. ACS Med Chem Lett7:408-12 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase pim-1 |
---|
Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
|
|
|
BDBM50174157 |
---|
n/a |
---|
Name | BDBM50174157 |
Synonyms: | CHEMBL3808942 |
Type | Small organic molecule |
Emp. Form. | C20H21N5O |
Mol. Mass. | 347.4136 |
SMILES | [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r| |
Structure |
|