| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50174146 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1581411 (CHEMBL3812018) |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Cee, VJ; Chavez, F; Herberich, B; Lanman, BA; Pettus, LH; Reed, AB; Wu, B; Wurz, RP; Andrews, KL; Chen, J; Hickman, D; Laszlo, J; Lee, MR; Guerrero, N; Mattson, BK; Nguyen, Y; Mohr, C; Rex, K; Sastri, CE; Wang, P; Wu, Q; Wu, T; Xu, Y; Zhou, Y; Winston, JT; Lipford, JR; Tasker, AS; Wang, HL Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. ACS Med Chem Lett7:408-12 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50174146 |
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| n/a |
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| Name | BDBM50174146 |
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| Synonyms: | CHEMBL3809691 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O |
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| Mol. Mass. | 359.4243 |
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| SMILES | [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C/C2)nc13 |r,c:25| |
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| Structure | 
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