| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 4 |
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| Ligand | BDBM50011360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580632 (CHEMBL3810794) |
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| IC50 | 4400±n/a nM |
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| Citation |  Wild, CT; Zhu, Y; Na, Y; Mei, F; Ynalvez, MA; Chen, H; Cheng, X; Zhou, J Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. ACS Med Chem Lett7:460-4 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 4 |
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| Name: | Rap guanine nucleotide exchange factor 4 |
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| Synonyms: | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115526.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504794 |
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| Residue: | 1011 |
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| Sequence: | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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| BDBM50011360 |
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| n/a |
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| Name | BDBM50011360 |
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| Synonyms: | CHEMBL3260990 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15ClN4O2 |
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| Mol. Mass. | 330.769 |
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| SMILES | CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N |
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| Structure | 
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