| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine protease hepsin |
|---|
| Ligand | BDBM50106240 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1589258 (CHEMBL3830286) |
|---|
| IC50 | 2600±n/a nM |
|---|
| Citation |  Subedi, M; Minn, I; Chen, J; Kim, Y; Ok, K; Jung, YW; Pomper, MG; Byun, Y Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands. Eur J Med Chem118:208-218 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine protease hepsin |
|---|
| Name: | Serine protease hepsin |
|---|
| Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45016.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
|---|
| Residue: | 417 |
|---|
| Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
|
|
|
|---|
| BDBM50106240 |
|---|
| n/a |
|---|
| Name | BDBM50106240 |
|---|
| Synonyms: | 6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine | CHEMBL339902 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16ClN3O |
|---|
| Mol. Mass. | 361.824 |
|---|
| SMILES | NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
