Reaction Details |
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Target | Renin |
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Ligand | BDBM50195229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1617511 (CHEMBL3859580) |
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IC50 | 4.5±n/a nM |
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Citation | Imaeda, Y; Tawada, M; Suzuki, S; Tomimoto, M; Kondo, M; Tarui, N; Sanada, T; Kanagawa, R; Snell, G; Behnke, CA; Kubo, K; Kuroita, T Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg Med Chem24:5771-5780 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50195229 |
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n/a |
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Name | BDBM50195229 |
Synonyms: | CHEMBL3944198 |
Type | Small organic molecule |
Emp. Form. | C22H35Cl2N5O2 |
Mol. Mass. | 472.452 |
SMILES | Cl.Cl.CCCN(C1CCCNC1)C(=O)c1cnc(nc1NCc1ccco1)C(C)(C)C |
Structure |
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