| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 18 |
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| Ligand | BDBM17636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619068 (CHEMBL3861237) |
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| EC50 | 474000±n/a nM |
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| Citation |  Monteillier, A; Loucif, A; Omoto, K; Stevens, EB; Lainez, S; Saintot, PP; Cao, L; Pryde, DC Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K Bioorg Med Chem Lett26:4919-4924 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 18 |
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| Name: | Potassium channel subfamily K member 18 |
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| Synonyms: | KCNK18 | KCNKI_HUMAN | Potassium channel subfamily K member 18 | TRESK | TRIK | TWIK-related individual potassium channel | TWIK-related spinal cord potassium channel |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43672.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105638 |
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| Residue: | 384 |
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| Sequence: | MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEK
FLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYG
YIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKW
CPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTL
QLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAI
LPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQN
RLIDIYKNVMLFFAKGKFYHLVKK
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| BDBM17636 |
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| n/a |
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| Name | BDBM17636 |
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| Synonyms: | 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | Arlef | CHEMBL23588 | Flufenamic acid | Nichisedan | US20240002326, Compound Flufenamic acid | US9271961, Flufenamic Acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10F3NO2 |
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| Mol. Mass. | 281.2299 |
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| SMILES | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F |
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| Structure | 
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