| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase EHMT2 |
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| Ligand | BDBM50202440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1624147 |
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| IC50 | 6500±n/a nM |
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| Citation |  Kondengaden, SM; Luo, LF; Huang, K; Zhu, M; Zang, L; Bataba, E; Wang, R; Luo, C; Wang, B; Li, KK; Wang, PG Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines. Eur J Med Chem122:382-393 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase EHMT2 |
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| Name: | Histone-lysine N-methyltransferase EHMT2 |
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| Synonyms: | Bat8 | EHMT2_MOUSE | Ehmt2 | Euchromatic histone-lysine N-methyltransferase 2 | G9a | H3-K9-HMTase 3 | HLA-B-associated transcript 8 | Histone H3-K9 methyltransferase 3 | Ng36 | Protein G9a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138019.66 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1294296 |
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| Residue: | 1263 |
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| Sequence: | MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGL
TGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAG
PSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACP
SRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKT
MSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGD
IILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEE
EEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRA
KEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCS
CRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRAR
MVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVT
IPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSG
PSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVI
LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV
NNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWT
PIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAV
NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKL
RLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRN
ITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSC
KNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLF
DLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTG
EELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPP
INT
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| BDBM50202440 |
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| n/a |
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| Name | BDBM50202440 |
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| Synonyms: | CHEMBL3933828 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31F6N3O2 |
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| Mol. Mass. | 579.5765 |
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| SMILES | CN(C)C(=O)Nc1ccc(CN2CCC(CC2)C(O)(c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C(F)(F)F)cc1 |
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| Structure | 
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