Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM50202474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1624267 (CHEMBL3866679) |
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IC50 | 150±n/a nM |
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Citation | Levent, S; Gerstmeier, J; Olgaç, A; Nikels, F; Garscha, U; Carotti, A; Macchiarulo, A; Werz, O; Banoglu, E; Çaliskan, B Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem122:510-519 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM50202474 |
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n/a |
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Name | BDBM50202474 |
Synonyms: | CHEMBL3897558 |
Type | Small organic molecule |
Emp. Form. | C33H32F3N3O |
Mol. Mass. | 543.6219 |
SMILES | CC(C)Cc1ccc(cc1)C(C)c1nc2cc(OCc3ccccn3)ccc2n1Cc1ccccc1C(F)(F)F |
Structure |
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