| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 4 |
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| Ligand | BDBM50202481 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1624369 (CHEMBL3866781) |
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| IC50 | 4900±n/a nM |
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| Citation |  Vasas, A; Forgo, P; Orvos, P; Tálosi, L; Csorba, A; Pinke, G; Hohmann, J Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects. J Nat Prod79:1990-2004 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 4 |
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| Name: | G protein-activated inward rectifier potassium channel 4 |
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| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47658.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107914 |
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| Residue: | 419 |
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| Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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| BDBM50202481 |
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| n/a |
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| Name | BDBM50202481 |
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| Synonyms: | CHEMBL3901192 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H49NO14 |
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| Mol. Mass. | 755.8047 |
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| SMILES | [H][C@@]12C[C@](C)(OC(C)=O)[C@]1([H])[C@@]1([H])[C@@]3(C)OC[C@@]1([C@H](OC(C)=O)[C@@]1([H])[C@@H](OC(=O)c4cccnc4)[C@@H](C)C[C@]1(OC(C)=O)[C@H]3OC(C)=O)C(=O)[C@@H]2OC(=O)C(C)CC |r| |
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| Structure | 
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