| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50435777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1624778 (CHEMBL3867190) |
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| IC50 | 76±n/a nM |
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| Citation |  Zak, M; Yuen, PW; Liu, X; Patel, S; Sampath, D; Oeh, J; Liederer, BM; Wang, W; O'Brien, T; Xiao, Y; Skelton, N; Hua, R; Sodhi, J; Wang, Y; Zhang, L; Zhao, G; Zheng, X; Ho, YC; Bair, KW; Dragovich, PS Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. J Med Chem59:8345-68 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM50435777 |
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| n/a |
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| Name | BDBM50435777 |
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| Synonyms: | CHEMBL2393163 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N5O3S |
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| Mol. Mass. | 429.536 |
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| SMILES | O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 |
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| Structure | 
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