| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50204261 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1627093 (CHEMBL3869614) |
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| Ki | 2.7±n/a nM |
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| Citation |  Dressman, BA; Tromiczak, EG; Chappell, MD; Tripp, AE; Quimby, SJ; Vetman, T; Fivush, AM; Matt, J; Jaramillo, C; Li, R; Khilevich, A; Blanco, MJ; Smith, SC; Carpintero, M; de Diego, JE; Barberis, M; García-Cerrada, S; Soriano, JF; Schkeryantz, JM; Witkin, JM; Wafford, KA; Seidel, W; Britton, T; Overshiner, CD; Li, X; Wang, XS; Heinz, BA; Catlow, JT; Swanson, S; Bedwell, D; Ornstein, PL; Mitch, CH Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorg Med Chem Lett26:5663-5668 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98889.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50204261 |
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| n/a |
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| Name | BDBM50204261 |
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| Synonyms: | CHEMBL3969063 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16Cl2N4O5S |
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| Mol. Mass. | 459.304 |
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| SMILES | [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2Sc1nc[nH]n1)C(O)=O |r| |
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| Structure | 
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