| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
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| Ligand | BDBM50204257 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1627037 (CHEMBL3869558) |
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| EC50 | >25000±n/a nM |
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| Citation |  Dressman, BA; Tromiczak, EG; Chappell, MD; Tripp, AE; Quimby, SJ; Vetman, T; Fivush, AM; Matt, J; Jaramillo, C; Li, R; Khilevich, A; Blanco, MJ; Smith, SC; Carpintero, M; de Diego, JE; Barberis, M; García-Cerrada, S; Soriano, JF; Schkeryantz, JM; Witkin, JM; Wafford, KA; Seidel, W; Britton, T; Overshiner, CD; Li, X; Wang, XS; Heinz, BA; Catlow, JT; Swanson, S; Bedwell, D; Ornstein, PL; Mitch, CH Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorg Med Chem Lett26:5663-5668 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 4 |
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| Name: | Metabotropic glutamate receptor 4 |
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| Synonyms: | GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4 |
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| Type: | Protein |
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| Mol. Mass.: | 101899.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14833 |
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| Residue: | 912 |
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| Sequence: | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI
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| BDBM50204257 |
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| n/a |
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| Name | BDBM50204257 |
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| Synonyms: | CHEMBL3947221 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15Cl2NO6 |
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| Mol. Mass. | 376.189 |
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| SMILES | [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| |
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| Structure | 
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