| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease ATG4B |
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| Ligand | BDBM80861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628065 (CHEMBL3870650) |
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| IC50 | 316±n/a nM |
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| Citation |  Cleenewerck, M; Grootaert, MOJ; Gladysz, R; Adriaenssens, Y; Roelandt, R; Joossens, J; Lambeir, AM; De Meyer, GRY; Declercq, W; Augustyns, K; Martinet, W; Van der Veken, P Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay. Eur J Med Chem123:631-638 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease ATG4B |
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| Name: | Cysteine protease ATG4B |
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| Synonyms: | APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44279.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_47132611 |
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| Residue: | 393 |
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| Sequence: | MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
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| BDBM80861 |
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| n/a |
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| Name | BDBM80861 |
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| Synonyms: | 4-[2-(2-Cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-acetyl]-3,4-dihydro-1H-quinoxalin-2-one | 4-[2-(2-cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)sulfanylethanoyl]-1,3-dihydroquinoxalin-2-one | 4-[2-(2-cyclohexyl-5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]-1,3-dihydroquinoxalin-2-one | 4-[2-[(2-cyclohexyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]-1-oxoethyl]-1,3-dihydroquinoxalin-2-one | 4-[2-[(2-cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)thio]acetyl]-1,3-dihydroquinoxalin-2-one | MLS000555707 | SMR000173088 | cid_3203918 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O2S2 |
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| Mol. Mass. | 466.619 |
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| SMILES | Cc1sc2nc(nc(SCC(=O)N3CC(=O)Nc4ccccc34)c2c1C)C1CCCCC1 |
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| Structure | 
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