| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Ligand | BDBM50214634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158624 (CHEMBL765769) |
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| IC50 | 9500±n/a nM |
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| Citation |  Yoshida, K; Horikoshi, Y; Eta, M; Chikazawa, J; Ogishima, M; Fukuda, Y; Sato, H Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity. Bioorg Med Chem Lett8:2967-72 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Synonyms: | Steroid 5-alpha-reductase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 204723 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29788.29 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1441437 |
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| Residue: | 259 |
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| Sequence: | MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
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| Component 2 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28784.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_205054 |
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| Residue: | 254 |
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| Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
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| BDBM50214634 |
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| n/a |
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| Name | BDBM50214634 |
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| Synonyms: | CHEMBL101778 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H43N3O6 |
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| Mol. Mass. | 589.7217 |
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| SMILES | COc1ccccc1N1CCN(CCCCCCOc2ccc(cc2)C(=O)Nc2ccccc2OCCCC(O)=O)CC1 |
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| Structure | 
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