| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50217526 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144914 (CHEMBL749479) |
|---|
| IC50 | 1.9±n/a nM |
|---|
| Citation |  Nishi, T; Fukazawa, T; Ishibashi, K; Nakajima, K; Sugioka, Y; Iio, Y; Kurata, H; Itoh, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T Combined NK1 and NK2 tachykinin receptor antagonists: synthesis and structure-activity relationships of novel oxazolidine analogues. Bioorg Med Chem Lett9:875-80 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46261.42 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
|
|
|
|---|
| BDBM50217526 |
|---|
| n/a |
|---|
| Name | BDBM50217526 |
|---|
| Synonyms: | CHEMBL366972 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35Cl2N3O6 |
|---|
| Mol. Mass. | 616.532 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)C(=O)N1CO[C@@](CCN2CCC(O)(CC2)c2ccncc2)(C1)c1ccc(Cl)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
