Ki Summary

Reaction Details

Report a problem with these data

Target

D(3) dopamine receptor

Ligand

BDBM50218412

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_62585 (CHEMBL673113)

4.0±n/a nM

Citation

Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, M Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett10:2553-5 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM50218412

n/a

Name

BDBM50218412

Synonyms:

CHEMBL419487

Type

Small organic molecule

Emp. Form.

C30H35N3O2

Mol. Mass.

469.6178

SMILES

CC(=O)c1cccc(\C=C\C(=O)N[C@H]2CC[C@H](CCN3CCc4ccc(cc4CC3)C#N)CC2)c1 |wU:13.12,wD:16.16,(30.39,-20.53,;28.85,-20.54,;28.08,-21.89,;28.05,-19.19,;28.82,-17.86,;28.05,-16.53,;26.51,-16.53,;25.74,-17.86,;24.2,-17.86,;23.43,-16.53,;21.89,-16.52,;21.1,-17.85,;21.12,-15.17,;19.58,-15.17,;18.81,-16.5,;17.27,-16.5,;16.5,-15.17,;14.96,-15.15,;14.19,-13.82,;12.65,-13.8,;11.98,-12.41,;10.48,-12.07,;9.29,-13.03,;7.96,-12.26,;6.63,-13.03,;6.63,-14.57,;7.96,-15.34,;9.29,-14.57,;10.48,-15.52,;11.98,-15.17,;5.28,-15.34,;3.93,-16.11,;17.27,-13.82,;18.81,-13.82,;26.51,-19.19,)|

Structure