Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50218413

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_62585 (CHEMBL673113)

10.0±n/a nM

Citation

Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, M Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett10:2553-5 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM50218413

n/a

Name

BDBM50218413

Synonyms:

CHEMBL87753

Type

Small organic molecule

Emp. Form.

C29H32N4O2

Mol. Mass.

468.59

SMILES

Oc1ccc2ccc(cc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1 |wU:14.15,wD:17.19,(29.92,-11.74,;28.57,-10.97,;28.57,-9.43,;27.24,-8.66,;25.91,-9.43,;24.58,-8.66,;23.23,-9.43,;23.23,-10.97,;24.58,-11.74,;25.91,-10.97,;27.24,-11.74,;21.9,-11.74,;21.88,-13.28,;20.55,-10.96,;19.24,-11.73,;19.24,-13.28,;17.91,-14.05,;16.56,-13.28,;15.21,-14.05,;15.2,-15.61,;13.87,-16.38,;12.53,-15.61,;11.1,-16.17,;10.64,-17.64,;9.1,-17.77,;8.43,-19.15,;9.34,-20.43,;10.87,-20.29,;11.53,-18.9,;13.04,-19.03,;14.09,-17.91,;8.71,-21.86,;8.09,-23.28,;16.56,-11.73,;17.89,-10.96,)|

Structure