Reaction Details |
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Target | Thioredoxin reductase 3 |
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Ligand | BDBM50218810 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_210422 (CHEMBL811694) |
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IC50 | 50000±n/a nM |
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Citation | Wipf, P; Hopkins, TD; Jung, JK; Rodriguez, S; Birmingham, A; Southwick, EC; Lazo, JS; Powis, G New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. Bioorg Med Chem Lett11:2637-41 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thioredoxin reductase 3 |
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Name: | Thioredoxin reductase 3 |
Synonyms: | TGR | TGR | TRXR3 | TRXR3_HUMAN | TXNRD3 | Thioredoxin and glutathione reductase | Thioredoxin reductase 3 | Thioredoxin reductase TR2 |
Type: | PROTEIN |
Mol. Mass.: | 70543.23 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104858 |
Residue: | 642 |
Sequence: | MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLV
GLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTV
PNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGK
KVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRH
NWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQ
FVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDV
TVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG
TETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDIL
EDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKK
ENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAM
KCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCG
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BDBM50218810 |
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n/a |
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Name | BDBM50218810 |
Synonyms: | CHEMBL91726 |
Type | Small organic molecule |
Emp. Form. | C23H14O4 |
Mol. Mass. | 354.3549 |
SMILES | O=C1C=CC2(Oc3cccc4cccc(O2)c34)c2cccc(OCC#C)c12 |c:2| |
Structure |
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