Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50219200

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_62455 (CHEMBL679227)

5.0±n/a nM

Citation

Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, MD Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett11:685-8 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM50219200

n/a

Name

BDBM50219200

Synonyms:

CHEMBL158627

Type

Small organic molecule

Emp. Form.

C26H31FN2O4S

Mol. Mass.

486.599

SMILES

CS(=O)(=O)Oc1ccc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)\C=C\c3ccc(F)cc3)Cc2c1 |wU:16.19,wD:13.12,(-.65,-16.53,;-.63,-15,;-2.01,-14.31,;-.33,-13.47,;.91,-14.92,;2.24,-14.15,;2.24,-12.6,;3.57,-11.83,;4.9,-12.58,;6.37,-12.09,;7.29,-13.35,;8.62,-12.58,;9.96,-13.35,;11.29,-12.56,;12.62,-13.33,;13.94,-12.56,;13.94,-11.02,;12.62,-10.25,;11.29,-11.02,;15.28,-10.27,;16.61,-11.04,;16.61,-12.58,;17.94,-10.27,;19.27,-11.04,;20.6,-10.27,;21.93,-11.04,;23.27,-10.27,;23.27,-8.73,;24.36,-7.64,;21.93,-7.96,;20.6,-8.73,;6.39,-14.61,;4.91,-14.14,;3.58,-14.92,)|

Structure