| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
|---|
| Ligand | BDBM50219333 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_154565 (CHEMBL761913) |
|---|
| IC50 | 2310±n/a nM |
|---|
| Citation |  Barnes, MJ; Cooper, N; Davenport, RJ; Dyke, HJ; Galleway, FP; Galvin, FC; Gowers, L; Haughan, AF; Lowe, C; Meissner, JW; Montana, JG; Morgan, T; Picken, CL; Watson, RJ Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors. Bioorg Med Chem Lett11:1081-3 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
|---|
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
|---|
| Synonyms: | Phosphodiesterase 7 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 302392 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51842.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NP56 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
|
|
|
|---|
| Component 2 |
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55514.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13946 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
|
|
|
|---|
| BDBM50219333 |
|---|
| n/a |
|---|
| Name | BDBM50219333 |
|---|
| Synonyms: | CHEMBL11073 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13BrN6O3 |
|---|
| Mol. Mass. | 405.206 |
|---|
| SMILES | Nc1nc(O)c2nc(Br)n(C3CCCc4ccc(cc34)[N+]([O-])=O)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
