Ki Summary

Reaction Details

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Target

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Ligand

BDBM50135599

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_208267 (CHEMBL813227)

IC50

17.6±n/a nM

Citation

Hotoda, H; Daigo, M; Furukawa, M; Murayama, K; Hasegawa, CA; Kaneko, M; Muramatsu, Y; Ishii, MM; Miyakoshi, S; Takatsu, T; Inukai, M; Kakuta, M; Abe, T; Fukuoka, T; Utsui, Y; Ohya, S Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds. Bioorg Med Chem Lett13:2833-6 (2003) [PubMed]

More Info.:

Get all data from this article, Assay Method

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Name:

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Synonyms:

MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX

Type:

PROTEIN

Mol. Mass.:

39889.38

Organism:

Escherichia coli (strain K12)

Description:

ChEMBL_1454117

Residue:

360

Sequence:

MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRND
GPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKV
VRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLA
YFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVE
TLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR

BDBM50135599

n/a

Name

BDBM50135599

Synonyms:

(4S,5S,6S)-6-{(R)-Carbamoyl-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-methoxy}-4,5-dihydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid ((S)-2-oxo-azepan-3-yl)-amide | CHEMBL96695

Type

Small organic molecule

Emp. Form.

C23H31N5O12

Mol. Mass.

569.5185

SMILES

CO[C@H]1[C@@H](O)[C@@H](O[C@@H]1[C@@H](O[C@H]1OC(=C[C@H](O)[C@@H]1O)C(=O)N[C@H]1CCCCNC1=O)C(N)=O)n1ccc(=O)[nH]c1=O |c:13|

Structure