Ki Summary

Reaction Details

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Target

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Ligand

BDBM50221512

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_208265 (CHEMBL813225)

IC50

63.1±n/a nM

Citation

Hotoda, H; Daigo, M; Furukawa, M; Murayama, K; Hasegawa, CA; Kaneko, M; Muramatsu, Y; Ishii, MM; Miyakoshi, S; Takatsu, T; Inukai, M; Kakuta, M; Abe, T; Fukuoka, T; Utsui, Y; Ohya, S Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds. Bioorg Med Chem Lett13:2833-6 (2003) [PubMed]

More Info.:

Get all data from this article, Assay Method

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Name:

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Synonyms:

MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX

Type:

PROTEIN

Mol. Mass.:

39889.38

Organism:

Escherichia coli (strain K12)

Description:

ChEMBL_1454117

Residue:

360

Sequence:

MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRND
GPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKV
VRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLA
YFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVE
TLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR

BDBM50221512

n/a

Name

BDBM50221512

Synonyms:

CHEMBL318366

Type

Small organic molecule

Emp. Form.

C30H43N5O13

Mol. Mass.

681.6881

SMILES

[H][C@@]1(O[C@H]([C@H](OC(=O)CCCCC)[C@@H]1OC)n1ccc(=O)[nH]c1=O)[C@@H](O[C@H]1OC(=C[C@H](O)[C@@H]1O)C(=O)N[C@H]1CCC[C@@H](C)NC1=O)C(N)=O |c:30|

Structure