| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Ligand | BDBM50026636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33139 (CHEMBL642094) |
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| Ki | 316±n/a nM |
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| Citation |  Clark, RD; Repke, DB; Berger, J; Nelson, JT; Kilpatrick, AT; Brown, CM; MacKinnon, AC; Clague, RU; Spedding, M Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors. J Med Chem34:705-17 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Name: | Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor |
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| Synonyms: | Adrenergic receptor alpha-1 | Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor | alpha-1 Adrenergic Receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 303470 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Alpha-1B adrenergic receptor |
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| Synonyms: | ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 56606.71 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Receptor binding assays were performed using rat cortical membranes. |
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| Residue: | 515 |
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| Sequence: | MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLP
SASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESP
GTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
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| Component 2 |
| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A |
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| Type: | Protein |
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| Mol. Mass.: | 51620.15 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P43140 |
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| Residue: | 466 |
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| Sequence: | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
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| Component 3 |
| Name: | Alpha-1D adrenergic receptor |
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| Synonyms: | ADA1D_RAT | Adra1a | Adra1d | Alpha adrenergic receptor 1A and 1D | Alpha-1D adrenergic receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 |
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| Type: | Protein |
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| Mol. Mass.: | 59375.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P23944 |
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| Residue: | 561 |
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| Sequence: | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDN
QSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRH
LQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILS
LCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFC
GITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRI
HCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF
VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR
RLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKP
ASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGA
EAVICQAYEPGDYSNLRETDI
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| BDBM50026636 |
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| n/a |
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| Name | BDBM50026636 |
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| Synonyms: | 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic acid methyl ester | CHEMBL10347 | RAUWOLSCINE HYDROCHLORIDE | alpha-yohimbine | corynanthidine | isoyohimbine | mesoyohimbine | methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate | methyl 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylate | rauwolscine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N2O3 |
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| Mol. Mass. | 354.4427 |
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| SMILES | COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| |
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| Structure | 
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