| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 6 |
|---|
| Ligand | BDBM50232968 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1649690 (CHEMBL3998824) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Cho, H; Sengupta, S; Jeon, SS; Hur, W; Choi, HG; Seo, HS; Lee, BJ; Kim, JH; Chung, M; Jeon, NL; Kim, ND; Sim, T Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277. J Med Chem60:1495-1508 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 6 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 6 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37494.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P52564 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
|
|
|
|---|
| BDBM50232968 |
|---|
| n/a |
|---|
| Name | BDBM50232968 |
|---|
| Synonyms: | CHEMBL4099337 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H26O7 |
|---|
| Mol. Mass. | 366.4055 |
|---|
| SMILES | COc1cc(O)c2c(CCC[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
