| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Smoothened homolog |
|---|
| Ligand | BDBM50233217 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1649906 (CHEMBL3999040) |
|---|
| IC50 | 13760±n/a nM |
|---|
| Citation |  Alfonsi, R; Botta, B; Cacchi, S; Di Marcotullio, L; Fabrizi, G; Faedda, R; Goggiamani, A; Iazzetti, A; Mori, M Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway. J Med Chem60:1469-1477 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Smoothened homolog |
|---|
| Name: | Smoothened homolog |
|---|
| Synonyms: | SMO_MOUSE | Smo | Smoh |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 87472.73 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1510377 |
|---|
| Residue: | 793 |
|---|
| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
|
|
|
|---|
| BDBM50233217 |
|---|
| n/a |
|---|
| Name | BDBM50233217 |
|---|
| Synonyms: | CHEMBL4090942 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H17NO3 |
|---|
| Mol. Mass. | 355.386 |
|---|
| SMILES | COc1cccc(c1)C(=O)c1c([nH]c2ccccc2c1=O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
