| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM28582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1651924 (CHEMBL4001179) |
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| Ki | 1.6±n/a nM |
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| Citation |  Odell, LR; Abdel-Hamid, MK; Hill, TA; Chau, N; Young, KA; Deane, FM; Sakoff, JA; Andersson, S; Daniel, JA; Robinson, PJ; McCluskey, A Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. J Med Chem60:349-361 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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| BDBM28582 |
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| n/a |
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| Name | BDBM28582 |
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| Synonyms: | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHEMBL6616 | DOI | DOI,(+) | DOI,(-) | [125I]2,5-dimethoxy-4-iodoamphetamine | [125I]4-iodo-2,5-dimethoxyphenylisopropylamine | [125I]DOI |
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| Type | radiolabeled ligand |
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| Emp. Form. | C11H16INO2 |
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| Mol. Mass. | 321.1547 |
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| SMILES | COc1cc(CC(C)N)c(OC)cc1I |
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| Structure | 
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