| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM50385534 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658603 (CHEMBL4008215) |
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| IC50 | 2800±n/a nM |
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| Citation |  Ju, H; Zhang, J; Huang, B; Kang, D; Huang, B; Liu, X; Zhan, P Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives. J Med Chem60:3533-3551 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82573.84 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_64976 |
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| Residue: | 716 |
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| Sequence: | MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
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| BDBM50385534 |
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| n/a |
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| Name | BDBM50385534 |
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| Synonyms: | CHEMBL2040605 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N2O4 |
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| Mol. Mass. | 336.3413 |
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| SMILES | COc1ccc(C=c2[nH]c(=Cc3ccccc3)c(=O)n(O)c2=O)cc1 |w:10.10,6.5| |
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| Structure | 
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