| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM50082665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1659686 (CHEMBL4009298) |
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| IC50 | 790±n/a nM |
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| Citation |  Lu, W; Yao, X; Ouyang, P; Dong, N; Wu, D; Jiang, X; Wu, Z; Zhang, C; Xu, Z; Tang, Y; Zou, S; Liu, M; Li, J; Zeng, M; Lin, P; Cheng, F; Huang, J Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem60:1817-1828 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_MOUSE | Leukotriene A4 hydrolase | Lta4h |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69048.58 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_936852 |
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| Residue: | 611 |
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| Sequence: | MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDL
TIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGES
HPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV
TTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK
EEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT
AMLVGRDLKVD
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| BDBM50082665 |
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| n/a |
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| Name | BDBM50082665 |
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| Synonyms: | 4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide | 4-Dimethylamino-N-(6-hydroxycarbamoyl-hexyl)-benzamide | CHEMBL140000 | US10188756, Compound CN52 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H25N3O3 |
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| Mol. Mass. | 307.388 |
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| SMILES | CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO |
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| Structure | 
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