| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50237047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1661450 |
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| IC50 | >10000±n/a nM |
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| Citation |  Hamed, MM; Darwish, SS; Herrmann, J; Abadi, AH; Engel, M First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-żB Activity As Novel Anticancer Agents. J Med Chem60:2853-2868 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 2 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 61201.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 540 |
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| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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| BDBM50237047 |
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| n/a |
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| Name | BDBM50237047 |
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| Synonyms: | CHEMBL4088718 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18BrN5S |
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| Mol. Mass. | 464.381 |
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| SMILES | Brc1cccc(Nc2ncnc3ccc(NC(=S)NCc4ccccc4)cc23)c1 |
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| Structure | 
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