| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 1 |
|---|
| Ligand | BDBM50033110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1659987 |
|---|
| IC50 | 14870±n/a nM |
|---|
| Citation |  Chen, EC; Khuri, N; Liang, X; Stecula, A; Chien, HC; Yee, SW; Huang, Y; Sali, A; Giacomini, KM Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem60:2685-2696 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 1 |
|---|
| Name: | Solute carrier family 22 member 1 |
|---|
| Synonyms: | Adrenergic Alpha | OCT1 | Organic cation transporter 1 | S22A1_HUMAN | SLC22A1 | Solute carrier family 22 member 1 | hOCT1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 61154.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Adrenergic Alpha 0 HUMAN::O15245 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL
GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT
PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN
TIYLKVQTSEPSGT
|
|
|
|---|
| BDBM50033110 |
|---|
| n/a |
|---|
| Name | BDBM50033110 |
|---|
| Synonyms: | ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H27N5O4 |
|---|
| Mol. Mass. | 389.4488 |
|---|
| SMILES | COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1 |
|---|
| Structure | 
|
|---|
Search and Browse
