| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Intestinal-type alkaline phosphatase |
|---|
| Ligand | BDBM50237943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1662570 (CHEMBL4012251) |
|---|
| IC50 | 4650±n/a nM |
|---|
| Citation |  Salar, U; Khan, KM; Iqbal, J; Ejaz, SA; Hameed, A; Al-Rashida, M; Perveen, S; Tahir, MN Coumarin sulfonates: New alkaline phosphatase inhibitors; in vitro and in silico studies. Eur J Med Chem131:29-47 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Intestinal-type alkaline phosphatase |
|---|
| Name: | Intestinal-type alkaline phosphatase |
|---|
| Synonyms: | ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56804.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1278525 |
|---|
| Residue: | 528 |
|---|
| Sequence: | MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLG
DGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLC
GVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYA
HTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADA
SQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD
PTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERA
GQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF
NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHV
MAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
|
|
|
|---|
| BDBM50237943 |
|---|
| n/a |
|---|
| Name | BDBM50237943 |
|---|
| Synonyms: | CHEMBL4086241 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H9ClN2O9S |
|---|
| Mol. Mass. | 440.769 |
|---|
| SMILES | Cc1cc(=O)oc2c(c(OS(=O)(=O)c3ccc(Cl)c(c3)[N+]([O-])=O)ccc12)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
