Reaction Details |
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Target | Kynurenine 3-monooxygenase |
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Ligand | BDBM50237998 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1662734 (CHEMBL4012415) |
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IC50 | 500±n/a nM |
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Citation | Liddle, J; Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett27:2023-2028 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine 3-monooxygenase |
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Name: | Kynurenine 3-monooxygenase |
Synonyms: | 1.14.13.9 | KMO_PSEFL | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase | PfKMO | kmo | qbsG |
Type: | PROTEIN |
Mol. Mass.: | 50713.22 |
Organism: | Pseudomonas fluorescens |
Description: | ChEMBL_117445 |
Residue: | 461 |
Sequence: | MTATDNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAER
GAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIWSINRDRLNRILLD
GAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEKRFHLLIGADGCNSAVRQAMASVV
DLGEHLETQPHGYKELQITPEASAQFNLEPNALHIWPHGDYMCIALPNLDRSFTVTLFLH
HQSPAAQPASPCFAQLVDGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTW
HVGGQAVLLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQPDAL
AIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLPYAQAMAR
GQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPLSHLC
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BDBM50237998 |
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n/a |
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Name | BDBM50237998 |
Synonyms: | CHEMBL1881960 |
Type | Small organic molecule |
Emp. Form. | C7H3Cl2NO2 |
Mol. Mass. | 204.01 |
SMILES | Oc1nc2cc(Cl)c(Cl)cc2o1 |
Structure |
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