| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 3 |
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| Ligand | BDBM50238541 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1663867 (CHEMBL4013548) |
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| IC50 | >100000±n/a nM |
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| Citation |  Mao, R; Shao, J; Zhu, K; Zhang, Y; Ding, H; Zhang, C; Shi, Z; Jiang, H; Sun, D; Duan, W; Luo, C Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem60:6289-6304 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 3 |
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| Name: | Protein arginine N-methyltransferase 3 |
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| Synonyms: | 2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59886.87 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_101368 |
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| Residue: | 531 |
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| Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
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| BDBM50238541 |
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| n/a |
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| Name | BDBM50238541 |
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| Synonyms: | CHEMBL4092336 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N3O4S |
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| Mol. Mass. | 371.41 |
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| SMILES | COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1 |
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| Structure | 
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