Reaction Details |
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Target | 5-hydroxytryptamine receptor 1B |
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Ligand | BDBM50013515 |
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Substrate/Competitor | n/a |
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Ki | 50.11±n/a nM |
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Comments | PDSP_1987 |
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Citation | Millan, MJ; Newman-Tancredi, A; Audinot, V; Cussac, D; Lejeune, F; Nicolas, JP; Cogé, F; Galizzi, JP; Boutin, JA; Rivet, JM; Dekeyne, A; Gobert, A Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse35:79-95 (2000) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 1B |
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Name: | 5-hydroxytryptamine receptor 1B |
Synonyms: | 5-HT1B | 5HT1B_CAVPO | HTR1B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43125.84 |
Organism: | GUINEA PIG |
Description: | 5-HT1B HTR1B GUINEA PIG::O08892 |
Residue: | 389 |
Sequence: | MGNPEASCTPPAVLGSQTGLPHANVSAPPNNCSAPSHIYQDSIALPWKVLLVVLLALITL
ATTLSNAFVIATVYRTRKLHTPANYLIASLAFTDLLVSILVMPISTMYTVTGRWTLGQAL
CDFWLSSDITCCTASIMHLCVIALDRYWAITDAVGYSAKRTPRRAAGMIALVWVFSICIS
LPPFFWRQAKAEEEVLDCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILK
QTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPEVPCDSGSPVYVNQVKVRVSDALLEK
KKLMAARERKATKTLGVILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFTWLGYLN
SLINPIIYTMSNEDFKQAFHKLIRFKCTT
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BDBM50013515 |
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n/a |
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Name | BDBM50013515 |
Synonyms: | (+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester | 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester | CHEMBL15245 | CORYNANTHINE | Johimbin | Quebrachin | RAUWOLSCINE | YOHIMBINE CHLORIDE | Yohimbin | Yohimbine | aphrodine | cid_8969 | corynine | methyl 17alpha-hydroxyyohimban-16alpha-carboxylate | quebrachine | yohimbic acid methyl ester |
Type | Small organic molecule |
Emp. Form. | C21H26N2O3 |
Mol. Mass. | 354.4427 |
SMILES | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| |
Structure |
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