Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGag-Pol polyprotein [588-1027]/[588-1147]
LigandBDBM3386
Substrate/Competitorpoly(rA):oligo(dT)(12-18)
Meas. Tech.HIV-1 RT Assay
IC50 0.6±n/a nM
Citation Livermore, DG; Bethell, RC; Cammack, N; Hancock, AP; Hann, MM; Green, DV; Lamont, RB; Noble, SA; Orr, DC; Payne, JJ Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines. J Med Chem36:3784-94 (1993) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [588-1027]/[588-1147]
Name:Gag-Pol polyprotein [588-1027]/[588-1147]
Synonyms:EC: 2.7.7.49 | HIV-1 Reverse Transcriptase
Type:Protein Complex
Mol. Mass.:115684
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [588-1147]
Synonyms:HIV-1 Reverse Transcriptase Chain A | POL_HV1H2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:64486.41
Organism:Human immunodeficiency virus type 1
Description:P04585[588-1147]
Residue:560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [588-1027]
Synonyms:HIV-1 Reverse Transcriptase Chain B | POL_HV1H2 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:51337.13
Organism:Human immunodeficiency virus type 1
Description:P04585[588-1027]
Residue:440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM3386
poly(rA):oligo(dT)(12-18)
Name:poly(rA):oligo(dT)(12-18)
Synonyms:n/a
Type:RNA/DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:[alpha-35S]TTP as co-substrate.
Residue:3
Sequence:
n/a