| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
|---|
| Ligand | BDBM84745 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 1000±n/a nM |
|---|
| Comments | PDSP_763 |
|---|
| Citation |  Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology25:871-80 (2001) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Glycine receptor subunit alpha-1 |
|---|
| Name: | Glycine receptor subunit alpha-1 |
|---|
| Synonyms: | GLRA1_RAT | Glra1 | Glycine receptor alpha-1 chain | Glycine receptor subunit alpha-1 | Glycine, non-strychnine | Glycine, strychnine | Glyr |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52629.37 |
|---|
| Organism: | RAT |
|---|
| Description: | Glycine, non-strychnine 0 RAT::P07727 |
|---|
| Residue: | 457 |
|---|
| Sequence: | MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
|
|
|
|---|
| BDBM84745 |
|---|
| n/a |
|---|
| Name | BDBM84745 |
|---|
| Synonyms: | CAS_136434-34-9 | DULOXETINE | LY-248686 | LY248686 | USRE49340, Rank 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19NOS |
|---|
| Mol. Mass. | 297.415 |
|---|
| SMILES | CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
