Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM50339607 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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pH | 7.5±0 |
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Temperature | 294.15±0 K |
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IC50 | >5.00e+5±n/a nM |
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Citation | Ward, RA; Brassington, C; Breeze, AL; Caputo, A; Critchlow, S; Davies, G; Goodwin, L; Hassall, G; Greenwood, R; Holdgate, GA; Mrosek, M; Norman, RA; Pearson, S; Tart, J; Tucker, JA; Vogtherr, M; Whittaker, D; Wingfield, J; Winter, J; Hudson, K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem55:3285-306 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
Type: | Protein |
Mol. Mass.: | 36694.85 |
Organism: | Homo sapiens (Human) |
Description: | P00338::PDB Code: 4ajp |
Residue: | 332 |
Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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BDBM50339607 |
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n/a |
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Name | BDBM50339607 |
Synonyms: | 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic Acid | CHEMBL1688790 | LDHA Inhibitor, 4 |
Type | Small organic molecule |
Emp. Form. | C16H10F3NO3 |
Mol. Mass. | 321.2507 |
SMILES | OC(=O)c1cc2c(cc(cc2n1O)-c1ccccc1)C(F)(F)F |
Structure |
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