Ki Summary

Reaction Details

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Target

Pyroglutamylated RF-amide peptide receptor

Ligand

BDBM86225

Substrate/Competitor

n/a

1500±n/a nM

Comments

PDSP_7188

Citation

Jiang, Y; Luo, L; Gustafson, EL; Yadav, D; Laverty, M; Murgolo, N; Vassileva, G; Zeng, M; Laz, TM; Behan, J; Qiu, P; Wang, L; Wang, S; Bayne, M; Greene, J; Monsma, F; Zhang, FL Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem278:27652-7 (2003) [PubMed] Article

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Pyroglutamylated RF-amide peptide receptor

Name:

Pyroglutamylated RF-amide peptide receptor

Synonyms:

GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49508.46

Organism:

Homo sapiens (Human)

Description:

GPR103 0 HUMAN::Q96P65

Residue:

431

Sequence:

MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALAL
FGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKM
VPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPM
WHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYE
LWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSN
FEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQ
RHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSE
LAENSPLDSGH

BDBM86225

n/a

Name

BDBM86225

Synonyms:

P51

Type

Small organic molecule

Emp. Form.

C49H72N18O11S

Mol. Mass.

1121.275

SMILES

C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O |r,wU:29.29,46.46,15.16,1.0,wD:35.35,57.58,5.12,(-3.35,-6.56,;-3.35,-5.02,;-2.03,-4.23,;-.66,-5.02,;-.66,-6.55,;.66,-4.23,;.66,-2.69,;-.67,-1.92,;-.2,-.45,;-1.44,.45,;-2.69,-.45,;-2.21,-1.92,;1.98,-5.02,;3.35,-4.23,;3.35,-2.69,;4.67,-5.02,;6.05,-4.23,;4.67,-6.55,;6.05,-7.34,;6.05,-8.87,;4.67,-9.67,;7.38,-9.64,;-4.73,-4.23,;-4.73,-2.69,;-6.05,-5.02,;-7.37,-4.23,;-8.74,-5.02,;-8.74,-6.55,;-10.06,-4.23,;-11.38,-5.02,;-11.38,-6.55,;-12.72,-7.32,;-12.76,-4.23,;-12.76,-2.69,;-14.08,-5.02,;-15.45,-4.23,;-15.45,-2.69,;-16.77,-1.9,;-16.77,-.36,;-18.1,.41,;-19.44,-.36,;-19.44,-1.9,;-20.53,.73,;-16.77,-5.02,;-16.77,-6.55,;-18.09,-4.23,;-19.46,-5.02,;-19.46,-6.55,;-20.8,-7.32,;-22.13,-6.55,;-23.47,-7.32,;-23.47,-8.86,;-22.13,-9.63,;-20.8,-8.86,;-20.79,-4.23,;-20.79,-2.69,;-22.11,-5.02,;-23.48,-4.23,;-23.48,-2.69,;-24.8,-1.9,;-24.8,-.37,;-26.13,.4,;-27.47,-.37,;-28.8,.4,;-27.47,-1.91,;-24.8,-4.97,;-24.8,-6.55,;-26.17,-4.23,;-27.51,-5,;-27.51,-6.54,;-28.84,-7.31,;-30.17,-6.54,;-31.51,-7.31,;-31.51,-8.85,;-30.17,-9.62,;-28.84,-8.85,;-28.84,-4.23,;-30.17,-5,;-28.84,-2.69,)|

Structure