Reaction Details |
| Report a problem with these data |
Target | 5-hydroxytryptamine receptor 3A |
---|
Ligand | BDBM91615 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. |
---|
pH | 7.4±n/a |
---|
Temperature | 310.15±n/a K |
---|
Ki | >30000±n/a nM |
---|
Citation | Yamauchi, JG; Gomez, K; Grimster, N; Dufouil, M; Nemecz, A; Fotsing, JR; Ho, K; Talley, TT; Sharpless, K; Fokin, VV; Taylor, P Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. Mol Pharmacol82:687-699 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5-hydroxytryptamine receptor 3A |
---|
Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3A Serotonin Receptor | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5HT3A_MOUSE | 5ht3 | Htr3 | Htr3a | Serotonin 3 receptor (5HT3) | Serotonin 3a (5-HT3a) receptor | Serotonin receptor 3A | Serotonin-gated ion channel receptor |
Type: | n/a |
Mol. Mass.: | 56056.00 |
Organism: | Mus musculus (house mouse) |
Description: | 5HT3A |
Residue: | 487 |
Sequence: | MRLCIPQVLLALFLSMLTAPGEGSRRRATQEDTTQPALLRLSDHLLANYKKGVRPVRDWR
KPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIW
VPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFT
SWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYV
IIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLP
ATIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCL
GEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREA
SLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTL
WSIWHYS
|
|
|
BDBM91615 |
---|
n/a |
---|
Name | BDBM91615 |
Synonyms: | 15q | alpha7 agonists 15q |
Type | n/a |
Emp. Form. | C19H24N5S2 |
Mol. Mass. | 386.557 |
SMILES | C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C2)n1cc(CSc2nc3ccccc3s2)nn1 |THB:10:8:1:5.4| |
Structure |
|