| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM102457 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 8±0 |
|---|
| IC50 | 41±0.0 nM |
|---|
| Citation |  Castro Palomino Laria, JC; Terricabras Belart, E; Erra Sola, M; Navarro Romero, E; Fonquerna Pou, S; Cardus Figueras, A; Lozoya Toribio, ME Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors US Patent US8536165 Publication Date 9/17/2013 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42881.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02127 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
|---|
| BDBM102457 |
|---|
| n/a |
|---|
| Name | BDBM102457 |
|---|
| Synonyms: | US8536165, 30 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N3O2 |
|---|
| Mol. Mass. | 325.4048 |
|---|
| SMILES | Cc1ccc(Nc2cnc(N3CCCCC3)c(C)c2)c(c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
