| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM405993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 0.636±n/a nM |
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| Citation |  Meng, D; Li, H; Yang, M; Ruiz, M; Dewnani, SV; Jian, T; Parker, Jr., DL; Zhang, T; Campeau, L; Wood, HB; Xu, J; Berger, R; Wu, JY; Orr, RK; Walsh, SP; Harper, B Factor IXa inhibitors US Patent US10351558 Publication Date 7/16/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM405993 |
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| n/a |
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| Name | BDBM405993 |
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| Synonyms: | US10351558, Example 168 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26ClN5O4 |
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| Mol. Mass. | 556.012 |
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| SMILES | COc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| |
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| Structure | 
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