| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM104186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PIM-2 Enzyme Assay |
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| pH | 7.4±0 |
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| Temperature | 295.15±0 K |
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| IC50 | 101±0.0 nM |
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| Citation |  Allen, S; Celeste, LL; Davis, TG; DeLisle, RK; Greschuk, JM; Gross, SD; Hicken, EJ; Jackson, LJ; Kallan, NC; Lyssikatos, JP; Marmsater, FP; Munson, MC; Pheneger, J; Rast, B; Robinson, JE; Schlachter, ST; Topalov, GT; Wright, AD; Zhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent US8575145 Publication Date 11/5/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM104186 |
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| n/a |
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| Name | BDBM104186 |
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| Synonyms: | US8575145, 63 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20BrN5O |
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| Mol. Mass. | 426.31 |
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| SMILES | CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(Br)cn12 |
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| Structure | 
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