| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transmembrane prolyl 4-hydroxylase |
|---|
| Ligand | BDBM105222 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Inhibition Assay |
|---|
| IC50 | 180±0.0 nM |
|---|
| Citation |  Jeske, M; Flamme, I; Stoll, F; Beck, H; Akbaba, M Substituted dihydropyrazolones and their use US Patent US8580778 Publication Date 11/12/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transmembrane prolyl 4-hydroxylase |
|---|
| Name: | Transmembrane prolyl 4-hydroxylase |
|---|
| Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56654.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NXG6 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
|
|
|
|---|
| BDBM105222 |
|---|
| n/a |
|---|
| Name | BDBM105222 |
|---|
| Synonyms: | US8580778, 25 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N8O2 |
|---|
| Mol. Mass. | 352.3506 |
|---|
| SMILES | O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cnc(c1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
