Compile Data Set for Download or QSAR

Found 74 hits with Last Name = 'jeske' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150313 (US8987248, 106) Show SMILES FC(F)(F)Oc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1ccccc1 Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)36-23-8-6-19(7-9-23)21-14-22(31-24(34)20-4-2-1-3-5-20)17-33(16-21)25(35)32-12-10-18(15-30)11-13-32/h1-9,18,21-22H,10-14,16-17H2,(H,31,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.05	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150314 (US8987248, 115) Show SMILES FC(F)(F)Oc1ccc(cc1)C1CC(CN(C1)C(=O)c1ccncc1)NC(=O)c1ccccc1 Show InChI InChI=1S/C25H22F3N3O3/c26-25(27,28)34-22-8-6-17(7-9-22)20-14-21(30-23(32)18-4-2-1-3-5-18)16-31(15-20)24(33)19-10-12-29-13-11-19/h1-13,20-21H,14-16H2,(H,30,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.1	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150322 (US8987248, 156) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1cccc(OC)c1 Show InChI InChI=1S/C28H34N4O3/c1-3-20-7-9-22(10-8-20)24-15-25(30-27(33)23-5-4-6-26(16-23)35-2)19-32(18-24)28(34)31-13-11-21(17-29)12-14-31/h4-10,16,21,24-25H,3,11-15,18-19H2,1-2H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.1	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150319 (US8987248, 133) Show SMILES C[C@@H]1CC[C@@H](C)N1C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)c1ccccc1 |r| Show InChI InChI=1S/C26H30F3N3O2/c1-17-8-9-18(2)32(17)25(34)31-15-21(19-10-12-22(13-11-19)26(27,28)29)14-23(16-31)30-24(33)20-6-4-3-5-7-20/h3-7,10-13,17-18,21,23H,8-9,14-16H2,1-2H3,(H,30,33)/t17-,18-,21?,23?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150320 (US8987248, 134) Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCS(=O)(=O)CC1)NC(=O)c1ccccc1 Show InChI InChI=1S/C24H26F3N3O4S/c25-24(26,27)20-8-6-17(7-9-20)19-14-21(28-22(31)18-4-2-1-3-5-18)16-30(15-19)23(32)29-10-12-35(33,34)13-11-29/h1-9,19,21H,10-16H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150315 (US8987248, 119) Show SMILES Cc1ccc(cc1C)C1CC(CN(C1)C(=O)C1(N)CCC1)NC(=O)c1ccccc1 Show InChI InChI=1S/C25H31N3O2/c1-17-9-10-20(13-18(17)2)21-14-22(27-23(29)19-7-4-3-5-8-19)16-28(15-21)24(30)25(26)11-6-12-25/h3-5,7-10,13,21-22H,6,11-12,14-16,26H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.7	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150317 (US8987248, 128) Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)c1ccccc1 Show InChI InChI=1S/C24H26F3N3O3/c25-24(26,27)20-8-6-17(7-9-20)19-14-21(28-22(31)18-4-2-1-3-5-18)16-30(15-19)23(32)29-10-12-33-13-11-29/h1-9,19,21H,10-16H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.0	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150307 (US8987248, 91) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCCC1)NC(=O)Nc1ccccc1 Show InChI InChI=1S/C25H32N4O2/c1-2-19-10-12-20(13-11-19)21-16-23(27-24(30)26-22-8-4-3-5-9-22)18-29(17-21)25(31)28-14-6-7-15-28/h3-5,8-13,21,23H,2,6-7,14-18H2,1H3,(H2,26,27,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150312 (US8987248, 105) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)OC(=O)Nc1ccccc1 Show InChI InChI=1S/C25H31N3O4/c1-2-19-8-10-20(11-9-19)21-16-23(32-24(29)26-22-6-4-3-5-7-22)18-28(17-21)25(30)27-12-14-31-15-13-27/h3-11,21,23H,2,12-18H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.4	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150305 (US8987248, 83) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)c1ccc(cn1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C32H34F3N3O2/c1-2-21-10-12-22(13-11-21)26-17-28(20-38(19-26)31(40)23-6-3-4-7-23)37-30(39)29-15-14-25(18-36-29)24-8-5-9-27(16-24)32(33,34)35/h5,8-16,18,23,26,28H,2-4,6-7,17,19-20H2,1H3,(H,37,39)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.7	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150324 (BDBM150325 | US8987248, 170) Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)C1CCCC1 Show InChI InChI=1S/C24H32F3N3O3/c25-24(26,27)19-7-5-16(6-8-19)18-13-20(28-22(32)17-3-1-2-4-17)15-30(14-18)23(33)29-11-9-21(31)10-12-29/h5-8,17-18,20-21,31H,1-4,9-15H2,(H,28,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21.3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150323 (US8987248, 162) Show SMILES Cc1cccc(n1)C(=O)NC1CC(CN(C1)C(=O)N1CCOCC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H27F3N4O3/c1-16-3-2-4-21(28-16)22(32)29-20-13-18(17-5-7-19(8-6-17)24(25,26)27)14-31(15-20)23(33)30-9-11-34-12-10-30/h2-8,18,20H,9-15H2,1H3,(H,29,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150301 (US8987248, 7) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C(C)(C)CF)C(=O)Nc1ccccc1 Show InChI InChI=1S/C25H31FN2O2/c1-4-18-10-12-19(13-11-18)20-14-21(23(29)27-22-8-6-5-7-9-22)16-28(15-20)24(30)25(2,3)17-26/h5-13,20-21H,4,14-17H2,1-3H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150318 (US8987248, 129) Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)c1ccccc1 Show InChI InChI=1S/C25H28F3N3O3/c26-25(27,28)20-8-6-17(7-9-20)19-14-21(29-23(33)18-4-2-1-3-5-18)16-31(15-19)24(34)30-12-10-22(32)11-13-30/h1-9,19,21-22,32H,10-16H2,(H,29,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118338 (US8653111, 62) Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150321 (US8987248, 141) Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCNC(=O)C1)NC(=O)c1ccccc1 Show InChI InChI=1S/C24H25F3N4O3/c25-24(26,27)19-8-6-16(7-9-19)18-12-20(29-22(33)17-4-2-1-3-5-17)14-31(13-18)23(34)30-11-10-28-21(32)15-30/h1-9,18,20H,10-15H2,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53.7	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150326 (US8987248, 178) Show SMILES FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)C1CCCC1 Show InChI InChI=1S/C25H31F3N4O2/c26-25(27,28)21-7-5-18(6-8-21)20-13-22(30-23(33)19-3-1-2-4-19)16-32(15-20)24(34)31-11-9-17(14-29)10-12-31/h5-8,17,19-20,22H,1-4,9-13,15-16H2,(H,30,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105221 (US8580778, 21) Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O Show InChI InChI=1S/C13H9F2N9O/c14-13(15)5-22(6-13)10-1-11(18-7-17-10)24-12(25)9(3-19-24)23-4-8(2-16)20-21-23/h1,3-4,7,19H,5-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150316 (US8987248, 121) Show SMILES CC(C)c1cccc(c1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)c1ccccc1 Show InChI InChI=1S/C26H33N3O3/c1-19(2)21-9-6-10-22(15-21)23-16-24(27-25(30)20-7-4-3-5-8-20)18-29(17-23)26(31)28-11-13-32-14-12-28/h3-10,15,19,23-24H,11-14,16-18H2,1-2H3,(H,27,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	79.9	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150324 (BDBM150325 | US8987248, 170) Show SMILES OC1CCN(CC1)C(=O)N1CC(CC(C1)c1ccc(cc1)C(F)(F)F)NC(=O)C1CCCC1 Show InChI InChI=1S/C24H32F3N3O3/c25-24(26,27)19-7-5-16(6-8-19)18-13-20(28-22(32)17-3-1-2-4-17)15-30(14-18)23(33)29-11-9-21(31)10-12-29/h5-8,17-18,20-21,31H,1-4,9-15H2,(H,28,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105220 (US8580778, 20) Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C#N)c1=O Show InChI InChI=1S/C14H10F2N8O/c15-14(16)5-23(6-14)11-1-12(19-7-18-11)24-13(25)10(3-21-24)22-4-9(2-17)20-8-22/h1,3-4,7-8,21H,5-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150304 (US8987248, 36) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)c1scnc1C)C(=O)Nc1ccccc1 Show InChI InChI=1S/C25H27N3O2S/c1-3-18-9-11-19(12-10-18)20-13-21(24(29)27-22-7-5-4-6-8-22)15-28(14-20)25(30)23-17(2)26-16-31-23/h4-12,16,20-21H,3,13-15H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98.2	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150302 (US8987248, 8) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)CCOC)C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H30N2O3/c1-3-18-9-11-19(12-10-18)20-15-21(17-26(16-20)23(27)13-14-29-2)24(28)25-22-7-5-4-6-8-22/h4-12,20-21H,3,13-17H2,1-2H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150309 (US8987248, 97) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)NC(C)(C)C Show InChI InChI=1S/C24H37N3O2/c1-5-17-10-12-18(13-11-17)20-14-21(25-23(29)26-24(2,3)4)16-27(15-20)22(28)19-8-6-7-9-19/h10-13,19-21H,5-9,14-16H2,1-4H3,(H2,25,26,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105219 (US8580778, 17) Show SMILES FC1(F)CCN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O Show InChI InChI=1S/C14H11F2N9O/c15-14(16)1-2-23(7-14)11-3-12(19-8-18-11)25-13(26)10(5-20-25)24-6-9(4-17)21-22-24/h3,5-6,8,20H,1-2,7H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150310 (US8987248, 102) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCOCC1)NC(=O)OC Show InChI InChI=1S/C20H29N3O4/c1-3-15-4-6-16(7-5-15)17-12-18(21-19(24)26-2)14-23(13-17)20(25)22-8-10-27-11-9-22/h4-7,17-18H,3,8-14H2,1-2H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	165	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105224 (US8580778, 29) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCO1)-n1cc(nn1)C#N Show InChI InChI=1S/C14H13N9O2/c15-6-10-8-21(20-19-10)11-7-18-23(14(11)24)13-5-12(16-9-17-13)22-3-1-2-4-25-22/h5,7-9,18H,1-4H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105222 (US8580778, 25) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cnc(c1)C#N Show InChI InChI=1S/C16H16N8O2/c17-7-12-9-23(11-20-12)13-8-21-24(16(13)25)15-6-14(18-10-19-15)22-2-1-4-26-5-3-22/h6,8-11,21H,1-5H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3527 (US8524699, 18) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1 Show InChI InChI=1S/C16H16N6O2/c23-16-13(12-2-1-3-17-9-12)10-20-22(16)15-8-14(18-11-19-15)21-4-6-24-7-5-21/h1-3,8-11,20H,4-7H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118341 (US8653111, 85) Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H18N6O2/c1-15(2,3)10-23-11-4-5-13(16-8-11)21-14(22)12(9-18-21)20-7-6-17-19-20/h4-9,18H,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150308 (US8987248, 95) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)N(C)c1ccccc1 Show InChI InChI=1S/C27H35N3O2/c1-3-20-13-15-21(16-14-20)23-17-24(19-30(18-23)26(31)22-9-7-8-10-22)28-27(32)29(2)25-11-5-4-6-12-25/h4-6,11-16,22-24H,3,7-10,17-19H2,1-2H3,(H,28,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	237	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150311 (US8987248, 104) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H34N2O3S/c1-2-20-12-14-22(15-13-20)24-16-25(18-28(17-24)26(29)23-10-6-7-11-23)27-32(30,31)19-21-8-4-3-5-9-21/h3-5,8-9,12-15,23-25,27H,2,6-7,10-11,16-19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	248	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM109268 (US8609698, 10) Show SMILES OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O Show InChI InChI=1S/C14H9BrN4O3/c15-10-3-9(4-16-6-10)11-7-18-19(13(11)20)12-2-1-8(5-17-12)14(21)22/h1-7,18H,(H,21,22)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...				US Patent US8609698 (2013) BindingDB Entry DOI: 10.7270/Q2G44NZ8
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118328 (US8653111, 7) Show SMILES Cc1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H10N6O/c1-8-2-3-12-10(6-8)17-11(18)9(7-14-17)16-5-4-13-15-16/h2-7,14H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118344 (US8653111, 103) Show SMILES CCSc1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H11N7OS/c1-2-20-10-5-9(12-7-13-10)18-11(19)8(6-15-18)17-4-3-14-16-17/h3-7,15H,2H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150306 (US8987248, 90) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1CCCC1)NC(=O)C(C)(C)C Show InChI InChI=1S/C24H36N2O2/c1-5-17-10-12-18(13-11-17)20-14-21(25-23(28)24(2,3)4)16-26(15-20)22(27)19-8-6-7-9-19/h10-13,19-21H,5-9,14-16H2,1-4H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	359	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118346 (US8653111, 129) Show SMILES CC1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H18N8O/c1-11-2-5-21(6-3-11)13-8-14(17-10-16-13)23-15(24)12(9-19-23)22-7-4-18-20-22/h4,7-11,19H,2-3,5-6H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105223 (US8580778, 26) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cc(nn1)C#N Show InChI InChI=1S/C15H15N9O2/c16-7-11-9-23(21-20-11)12-8-19-24(15(12)25)14-6-13(17-10-18-14)22-2-1-4-26-5-3-22/h6,8-10,19H,1-5H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3543 (US8524699, 16) Show SMILES Clc1ccc(cn1)-c1c[nH]n(-c2cc(ncn2)N2CCOCC2)c1=O Show InChI InChI=1S/C16H15ClN6O2/c17-13-2-1-11(8-18-13)12-9-21-23(16(12)24)15-7-14(19-10-20-15)22-3-5-25-6-4-22/h1-2,7-10,21H,3-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM150303 (US8987248, 18) Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)C1(CC)COC1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C26H32N2O3/c1-3-19-10-12-20(13-11-19)21-14-22(24(29)27-23-8-6-5-7-9-23)16-28(15-21)25(30)26(4-2)17-31-18-26/h5-13,21-22H,3-4,14-18H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	483	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...				US Patent US8987248 (2015) BindingDB Entry DOI: 10.7270/Q2QC027W
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1 Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118329 (US8653111, 10) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-n1ccnc1 Show InChI InChI=1S/C15H17N7O/c23-15-12(21-7-4-16-11-21)9-19-22(15)14-8-13(17-10-18-14)20-5-2-1-3-6-20/h4,7-11,19H,1-3,5-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105217 (US8580778, 5) Show SMILES OC(=O)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C14H13N7O3/c22-13-10(19-2-1-15-8-19)4-18-21(13)12-3-11(16-7-17-12)20-5-9(6-20)14(23)24/h1-4,7-9,18H,5-6H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118331 (US8653111, 17) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)C1CC1)-n1ccnn1 Show InChI InChI=1S/C12H11N7O/c20-12-10(18-4-3-15-17-18)6-16-19(12)11-5-9(8-1-2-8)13-7-14-11/h3-8,16H,1-2H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118347 (US8653111, 166) Show SMILES COC1CCCN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C16H19N7O2/c1-25-12-3-2-5-21(9-12)14-7-15(19-10-18-14)23-16(24)13(8-20-23)22-6-4-17-11-22/h4,6-8,10-12,20H,2-3,5,9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3555 (US8524699, 3) Show SMILES Cc1cc(C)n(n1)-c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C17H15N7O/c1-11-6-12(2)23(22-11)15-7-16(20-10-19-15)24-17(25)14(9-21-24)13-4-3-5-18-8-13/h3-10,21H,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118345 (US8653111, 113) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCSCC1)-n1ccnn1 Show InChI InChI=1S/C13H14N8OS/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118330 (US8653111, 12) Show SMILES OCc1ccc(nc1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O Show InChI InChI=1S/C13H10F3N5O2/c14-13(15,16)10-5-20(7-18-10)9-4-19-21(12(9)23)11-2-1-8(6-22)3-17-11/h1-5,7,19,22H,6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105218 (US8580778, 9) Show SMILES CN(C)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C14H17N9O/c1-20(2)10-7-21(8-10)12-5-13(16-9-15-12)23-14(24)11(6-18-23)22-4-3-17-19-22/h3-6,9-10,18H,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118333 (US8653111, 45) Show SMILES CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O Show InChI InChI=1S/C14H16N6O2/c1-9(2)11-7-19(18-17-11)12-6-16-20(14(12)22)13-4-3-10(8-21)5-15-13/h3-7,9,16,21H,8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair

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