| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM150307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 17.4±n/a nM |
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| Comments | extracted |
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| Citation |  Jeske, M; Heimbach, D; Röhrig, S; Cancho Grande, Y; Schneider, D; Rester, U; Bender, E; Meininghaus, M; Zimmermann, K; Zubov, D; Buchmüller, A; Von Degenfeld, G; Gerdes, C; Gerisch, M; Gnoth, MJ; Gericke, KM Substituted piperidines as Par-1 antagonists US Patent US8987248 Publication Date 3/24/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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| BDBM150307 |
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| n/a |
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| Name | BDBM150307 |
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| Synonyms: | US8987248, 91 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N4O2 |
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| Mol. Mass. | 420.5472 |
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| SMILES | CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCCC1)NC(=O)Nc1ccccc1 |
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| Structure | 
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