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Compile Data Set for Download or QSAR

Found 518 hits with Last Name = 'cancho grande' and Initial = 'y'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509092
PNG
(S-(1-{2-[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCOCCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.271n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509099
PNG
(4-{[(1R)-2-({2-[(3-Aminopropyl) {(1R)-1-[1-benzyl-...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCC(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.446n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509093
PNG
((3R,7S)-7-Amino-17-{[(2R)-2-amino-2-carboxyethyl]s...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCOCCNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.457n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509097
PNG
((2R,28R)-28-Amino-2-[({2-[(3-aminopropyl){(1R)-1-[...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CCNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.470n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509095
PNG
(S-(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CSC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.621n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509107
PNG
((1R,4R,27R,33R)-1-Amino-32-(3-aminopropyl)-33-[1-b...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.827n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509113
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)C[C@H](SC[C@H](N)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.944n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509102
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)C(CC(O)=O)SC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 0.964n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509096
PNG
(N-(3-Aminopropyl)-N-{(1R)-1-[1-benzyl-4-(2,5-diflu...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.07n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509098
PNG
(S-{2-[(3-Aminopropyl){(1R)-1-[1-benzyl-4-(2,5-difl...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](N)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.11n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509110
PNG
(N-{(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluo...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.26n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509102
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)C(CC(O)=O)SC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.48n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509090
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509107
PNG
((1R,4R,27R,33R)-1-Amino-32-(3-aminopropyl)-33-[1-b...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509091
PNG
(4-[(2-{[(2R)-2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)N[C@H](CNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.52n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509094
PNG
(2-{[(2R)-2-Amino-2-carboxyethyl]sulphanyl}-4-({(14...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSCCC(=O)NCCNC(=O)CNC(=O)CC(SCC[C@H](N)C(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 1.78n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509089
PNG
(S-[1-(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.01n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509102
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)C(CC(O)=O)SC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.03n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509090
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.16n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509108
PNG
((2R,24S,27R)-27-Amino-2-[({2-[(3-aminopropyl) {(1R...)
Show SMILES CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CNC(=O)C(CC(O)=O)SC[C@H](N)C(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.31n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM633516
PNG
(US11806404, Beispiele M100)
Show SMILES CC(=O)NC(CCCCNC(=O)CCC(N)C(O)=O)C(=O)NCCNC(=O)C(N)CCN([C@@H](c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F)C(C)(C)C)C(=O)CO |r|
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n/an/a 2.45n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509090
PNG
(4-[(2-{[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CNC(=O)CC(SC[C@H](N)C(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.45n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509106
PNG
(N6 (N-{(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-di...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCC(=O)NCCCC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.58n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509111
PNG
(N-{(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluo...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCC(=O)N[C@H](CCC(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.90n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509112
PNG
(N-{(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluo...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)N[C@H](CCC(O)=O)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 2.91n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509104
PNG
((2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluorop...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 4.17n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Kinesin-like protein KIF11


(Homo sapiens (Human))		BDBM509105
PNG
(N-[2-({(2S)-2-Amino-4-[{(1R)-1-[1-benzyl-4-(2,5-di...)
Show SMILES CC(C)(C)[C@@H](N(CC[C@H](N)C(=O)NCCNC(=O)CC[C@H](N)C(O)=O)C(=O)CO)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
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n/an/a 5.17n/an/an/an/an/an/a


TBA

Assay Description
The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2N30139
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298092
PNG
(3-[3-(2-tert-butoxyethyl)-1,2,4-oxadiazol-5-yl]-2-...)
Show SMILES Cc1nn2c(cc(=O)[nH]c2c1-c1nc(CCOC(C)(C)C)no1)C1CCNCC1
Show InChI InChI=1S/C20H28N6O3/c1-12-17(19-22-15(25-29-19)7-10-28-20(2,3)4)18-23-16(27)11-14(26(18)24-12)13-5-8-21-9-6-13/h11,13,21H,5-10H2,1-4H3,(H,23,27)
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n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150313
PNG
(US8987248, 106)
Show SMILES FC(F)(F)Oc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1ccccc1
Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)36-23-8-6-19(7-9-23)21-14-22(31-24(34)20-4-2-1-3-5-20)17-33(16-21)25(35)32-12-10-18(15-30)11-13-32/h1-9,18,21-22H,10-14,16-17H2,(H,31,34)
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US Patent
n/an/a 7.05n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298254
PNG
(3-(2-methylbutanoyl)-7-(piperidin-4-yl)pyrazolo[1,...)
Show SMILES CCC(C)C(=O)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298255
PNG
(3-(cyclopropylcarbonyl)-7-(piperidin-4-yl)pyrazolo...)
Show SMILES O=C(C1CC1)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C15H18N4O2/c20-13-7-12(9-3-5-16-6-4-9)19-15(18-13)11(8-17-19)14(21)10-1-2-10/h7-10,16H,1-6H2,(H,18,20)
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n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298041
PNG
(3-(2-methyl-1,3-thiazol-5-yl)-7-(piperidin-4-yl)py...)
Show SMILES Cc1ncc(s1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5OS/c1-9-17-8-13(22-9)11-7-18-20-12(6-14(21)19-15(11)20)10-2-4-16-5-3-10/h6-8,10,16H,2-5H2,1H3,(H,19,21)
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n/an/a 8.20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM297950
PNG
(7-(piperidin-4-yl)-3-{5-[4-(trifluoromethyl)phenyl...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1nnc(o1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C20H17F3N6O2/c21-20(22,23)13-3-1-12(2-4-13)18-27-28-19(31-18)14-10-25-29-15(9-16(30)26-17(14)29)11-5-7-24-8-6-11/h1-4,9-11,24H,5-8H2,(H,26,30)
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n/an/a 8.70n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298115
PNG
(7-(piperidin-4-yl)-3-(piperidin-1-ylcarbonyl)pyraz...)
Show SMILES O=C(N1CCCCC1)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C17H23N5O2/c23-15-10-14(12-4-6-18-7-5-12)22-16(20-15)13(11-19-22)17(24)21-8-2-1-3-9-21/h10-12,18H,1-9H2,(H,20,23)
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n/an/a 9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298123
PNG
(3-(4-cyclohexyl-1,3-thiazol-2-yl)-7-(piperidin-4-y...)
Show SMILES O=c1cc(C2CCNCC2)n2ncc(-c3nc(cs3)C3CCCCC3)c2[nH]1
Show InChI InChI=1S/C20H25N5OS/c26-18-10-17(14-6-8-21-9-7-14)25-19(24-18)15(11-22-25)20-23-16(12-27-20)13-4-2-1-3-5-13/h10-14,21H,1-9H2,(H,24,26)
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n/an/a 9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298009
PNG
(3-[3-(4-fluorobenzyl)-1,2,4-oxadiazol-5-yl]-7-(pip...)
Show SMILES Fc1ccc(Cc2noc(n2)-c2cnn3c(cc(=O)[nH]c23)C2CCNCC2)cc1
Show InChI InChI=1S/C20H19FN6O2/c21-14-3-1-12(2-4-14)9-17-24-20(29-26-17)15-11-23-27-16(10-18(28)25-19(15)27)13-5-7-22-8-6-13/h1-4,10-11,13,22H,5-9H2,(H,25,28)
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n/an/a 9.70n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298184
PNG
(Rel-3-{5-[(1R,2S)-2-methylcyclopentyl]-1,2,4-oxadi...)
Show SMILES CC1CCCC1c1nc(no1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
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n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298073
PNG
(3-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]-7-(pipe...)
Show SMILES O=c1cc(C2CCNCC2)n2ncc(-c3nnc(CCc4ccccc4)o3)c2[nH]1
Show InChI InChI=1S/C21H22N6O2/c28-18-12-17(15-8-10-22-11-9-15)27-20(24-18)16(13-23-27)21-26-25-19(29-21)7-6-14-4-2-1-3-5-14/h1-5,12-13,15,22H,6-11H2,(H,24,28)
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n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298246
PNG
(3-[3-(4-hydroxybenzyl)-1,2,4-oxadiazol-5-yl]-2-met...)
Show SMILES Cc1nn2c(cc(=O)[nH]c2c1-c1nc(Cc2ccc(O)cc2)no1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O3/c1-12-19(21-23-17(26-30-21)10-13-2-4-15(28)5-3-13)20-24-18(29)11-16(27(20)25-12)14-6-8-22-9-7-14/h2-5,11,14,22,28H,6-10H2,1H3,(H,24,29)
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n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298237
PNG
(3-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-met...)
Show SMILES COc1ccccc1-c1noc(n1)-c1c(C)nn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C21H22N6O3/c1-12-18(21-24-19(26-30-21)14-5-3-4-6-16(14)29-2)20-23-17(28)11-15(27(20)25-12)13-7-9-22-10-8-13/h3-6,11,13,22H,7-10H2,1-2H3,(H,23,28)
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n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM297791
PNG
(Ethyl 5-oxo-7-(piperidin-4-yl)-4,5-dihydropyrazolo...)
Show SMILES CCOC(=O)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C14H18N4O3/c1-2-21-14(20)10-8-16-18-11(7-12(19)17-13(10)18)9-3-5-15-6-4-9/h7-9,15H,2-6H2,1H3,(H,17,19)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298127
PNG
(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-methyl-7-(...)
Show SMILES Cc1nn2c(cc(=O)[nH]c2c1-c1nnc(o1)C(C)(C)C)C1CCNCC1
Show InChI InChI=1S/C18H24N6O2/c1-10-14(16-21-22-17(26-16)18(2,3)4)15-20-13(25)9-12(24(15)23-10)11-5-7-19-8-6-11/h9,11,19H,5-8H2,1-4H3,(H,20,25)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298161
PNG
(Cyclobutyl 2-methyl-5-oxo-7-(piperidin-4-yl)-4,5-d...)
Show SMILES Cc1nn2c(cc(=O)[nH]c2c1C(=O)OC1CCC1)C1CCNCC1
Show InChI InChI=1S/C17H22N4O3/c1-10-15(17(23)24-12-3-2-4-12)16-19-14(22)9-13(21(16)20-10)11-5-7-18-8-6-11/h9,11-12,18H,2-8H2,1H3,(H,19,22)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298170
PNG
(7-(piperidin-4-yl)-3-(1,2-thiazol-5-yl)pyrazolo[1,...)
Show SMILES O=c1cc(C2CCNCC2)n2ncc(-c3ccns3)c2[nH]1
Show InChI InChI=1S/C14H15N5OS/c20-13-7-11(9-1-4-15-5-2-9)19-14(18-13)10(8-16-19)12-3-6-17-21-12/h3,6-9,15H,1-2,4-5H2,(H,18,20)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298253
PNG
(3-(cyclopentylcarbonyl)-7-(piperidin-4-yl)pyrazolo...)
Show SMILES O=C(C1CCCC1)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C17H22N4O2/c22-15-9-14(11-5-7-18-8-6-11)21-17(20-15)13(10-19-21)16(23)12-3-1-2-4-12/h9-12,18H,1-8H2,(H,20,22)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM297845
PNG
(5-[5-Oxo-7-(piperidin-4-yl)-4,5-dihydropyrazolo[1,...)
Show SMILES O=c1cc(C2CCNCC2)n2ncc(-c3cc(cs3)C#N)c2[nH]1
Show InChI InChI=1S/C16H15N5OS/c17-7-10-5-14(23-9-10)12-8-19-21-13(6-15(22)20-16(12)21)11-1-3-18-4-2-11/h5-6,8-9,11,18H,1-4H2,(H,20,22)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298096
PNG
(2-methyl-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES Cc1nn2c(cc(=O)[nH]c2c1-c1nc(no1)-c1ccc(C)cc1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-3-5-15(6-4-12)19-24-21(29-26-19)18-13(2)25-27-16(11-17(28)23-20(18)27)14-7-9-22-10-8-14/h3-6,11,14,22H,7-10H2,1-2H3,(H,23,28)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298098
PNG
(3-(4-ethyl-1,3-thiazol-2-yl)-7-(piperidin-4-yl)pyr...)
Show SMILES CCc1csc(n1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Show InChI InChI=1S/C16H19N5OS/c1-2-11-9-23-16(19-11)12-8-18-21-13(7-14(22)20-15(12)21)10-3-5-17-6-4-10/h7-10,17H,2-6H2,1H3,(H,20,22)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM298063
PNG
(3-[5-(3-chlorobenzyl)-1,3,4-oxadiazol-2-yl]-7-(pip...)
Show SMILES Clc1cccc(Cc2nnc(o2)-c2cnn3c(cc(=O)[nH]c23)C2CCNCC2)c1
Show InChI InChI=1S/C20H19ClN6O2/c21-14-3-1-2-12(8-14)9-18-25-26-20(29-18)15-11-23-27-16(10-17(28)24-19(15)27)13-4-6-22-7-5-13/h1-3,8,10-11,13,22H,4-7,9H2,(H,24,28)
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n/an/a 11n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The clot-lysis test system configures the kinetics of clot formation and degradation in vitro and allows quantifying modulation of the process by sel...

US Patent US10118930 (2018)


BindingDB Entry DOI: 10.7270/Q2QC05J5
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM150322
PNG
(US8987248, 156)
Show SMILES CCc1ccc(cc1)C1CC(CN(C1)C(=O)N1CCC(CC1)C#N)NC(=O)c1cccc(OC)c1
Show InChI InChI=1S/C28H34N4O3/c1-3-20-7-9-22(10-8-20)24-15-25(30-27(33)23-5-4-6-26(16-23)35-2)19-32(18-24)28(34)31-13-11-21(17-29)12-14-31/h4-10,16,21,24-25H,3,11-15,18-19H2,1-2H3,(H,30,33)
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Similars
US Patent
n/an/a 11.1n/an/an/an/a7.525



Bayer Intellectual Property GmbH

US Patent


Assay Description
Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...

US Patent US8987248 (2015)


BindingDB Entry DOI: 10.7270/Q2QC027W
More data for this
Ligand-Target Pair
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