Compile Data Set for Download or QSAR

Found 40 hits with Last Name = 'akbaba' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118338 (US8653111, 62) Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105221 (US8580778, 21) Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O Show InChI InChI=1S/C13H9F2N9O/c14-13(15)5-22(6-13)10-1-11(18-7-17-10)24-12(25)9(3-19-24)23-4-8(2-16)20-21-23/h1,3-4,7,19H,5-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105220 (US8580778, 20) Show SMILES FC1(F)CN(C1)c1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C#N)c1=O Show InChI InChI=1S/C14H10F2N8O/c15-14(16)5-23(6-14)11-1-12(19-7-18-11)24-13(25)10(3-21-24)22-4-9(2-17)20-8-22/h1,3-4,7-8,21H,5-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105219 (US8580778, 17) Show SMILES FC1(F)CCN(C1)c1cc(ncn1)-n1[nH]cc(-n2cc(nn2)C#N)c1=O Show InChI InChI=1S/C14H11F2N9O/c15-14(16)1-2-23(7-14)11-3-12(19-8-18-11)25-13(26)10(5-20-25)24-6-9(4-17)21-22-24/h3,5-6,8,20H,1-2,7H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105224 (US8580778, 29) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCO1)-n1cc(nn1)C#N Show InChI InChI=1S/C14H13N9O2/c15-6-10-8-21(20-19-10)11-7-18-23(14(11)24)13-5-12(16-9-17-13)22-3-1-2-4-25-22/h5,7-9,18H,1-4H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3527 (US8524699, 18) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-c1cccnc1 Show InChI InChI=1S/C16H16N6O2/c23-16-13(12-2-1-3-17-9-12)10-20-22(16)15-8-14(18-11-19-15)21-4-6-24-7-5-21/h1-3,8-11,20H,4-7H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105222 (US8580778, 25) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cnc(c1)C#N Show InChI InChI=1S/C16H16N8O2/c17-7-12-9-23(11-20-12)13-8-21-24(16(13)25)15-6-14(18-10-19-15)22-2-1-4-26-5-3-22/h6,8-11,21H,1-5H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118341 (US8653111, 85) Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H18N6O2/c1-15(2,3)10-23-11-4-5-13(16-8-11)21-14(22)12(9-18-21)20-7-6-17-19-20/h4-9,18H,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118328 (US8653111, 7) Show SMILES Cc1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H10N6O/c1-8-2-3-12-10(6-8)17-11(18)9(7-14-17)16-5-4-13-15-16/h2-7,14H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118344 (US8653111, 103) Show SMILES CCSc1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H11N7OS/c1-2-20-10-5-9(12-7-13-10)18-11(19)8(6-15-18)17-4-3-14-16-17/h3-7,15H,2H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118346 (US8653111, 129) Show SMILES CC1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H18N8O/c1-11-2-5-21(6-3-11)13-8-14(17-10-16-13)23-15(24)12(9-19-23)22-7-4-18-20-22/h4,7-11,19H,2-3,5-6H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105223 (US8580778, 26) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCOCC1)-n1cc(nn1)C#N Show InChI InChI=1S/C15H15N9O2/c16-7-11-9-23(21-20-11)12-8-19-24(15(12)25)14-6-13(17-10-18-14)22-2-1-4-26-5-3-22/h6,8-10,19H,1-5H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3543 (US8524699, 16) Show SMILES Clc1ccc(cn1)-c1c[nH]n(-c2cc(ncn2)N2CCOCC2)c1=O Show InChI InChI=1S/C16H15ClN6O2/c17-13-2-1-11(8-18-13)12-9-21-23(16(12)24)15-7-14(19-10-20-15)22-3-5-25-6-4-22/h1-2,7-10,21H,3-6H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118339 (US8653111, 72) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1 Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118329 (US8653111, 10) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-n1ccnc1 Show InChI InChI=1S/C15H17N7O/c23-15-12(21-7-4-16-11-21)9-19-22(15)14-8-13(17-10-18-14)20-5-2-1-3-6-20/h4,7-11,19H,1-3,5-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105217 (US8580778, 5) Show SMILES OC(=O)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C14H13N7O3/c22-13-10(19-2-1-15-8-19)4-18-21(13)12-3-11(16-7-17-12)20-5-9(6-20)14(23)24/h1-4,7-9,18H,5-6H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118331 (US8653111, 17) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)C1CC1)-n1ccnn1 Show InChI InChI=1S/C12H11N7O/c20-12-10(18-4-3-15-17-18)6-16-19(12)11-5-9(8-1-2-8)13-7-14-11/h3-8,16H,1-2H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118347 (US8653111, 166) Show SMILES COC1CCCN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C16H19N7O2/c1-25-12-3-2-5-21(9-12)14-7-15(19-10-18-14)23-16(24)13(8-20-23)22-6-4-17-11-22/h4,6-8,10-12,20H,2-3,5,9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3555 (US8524699, 3) Show SMILES Cc1cc(C)n(n1)-c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C17H15N7O/c1-11-6-12(2)23(22-11)15-7-16(20-10-19-15)24-17(25)14(9-21-24)13-4-3-5-18-8-13/h3-10,21H,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118345 (US8653111, 113) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCSCC1)-n1ccnn1 Show InChI InChI=1S/C13H14N8OS/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118330 (US8653111, 12) Show SMILES OCc1ccc(nc1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O Show InChI InChI=1S/C13H10F3N5O2/c14-13(15,16)10-5-20(7-18-10)9-4-19-21(12(9)23)11-2-1-8(6-22)3-17-11/h1-5,7,19,22H,6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105218 (US8580778, 9) Show SMILES CN(C)C1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C14H17N9O/c1-20(2)10-7-21(8-10)12-5-13(16-9-15-12)23-14(24)11(6-18-23)22-4-3-17-19-22/h3-6,9-10,18H,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118333 (US8653111, 45) Show SMILES CC(C)c1cn(nn1)-c1c[nH]n(-c2ccc(CO)cn2)c1=O Show InChI InChI=1S/C14H16N6O2/c1-9(2)11-7-19(18-17-11)12-6-16-20(14(12)22)13-4-3-10(8-21)5-15-13/h3-7,9,16,21H,8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3591 (US8524699, 7) Show SMILES Clc1ccc(cc1)-c1nnc(s1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C16H10ClN5OS/c17-12-5-3-10(4-6-12)14-20-21-16(24-14)22-15(23)13(9-19-22)11-2-1-7-18-8-11/h1-9,19H	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	880	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM105216 (US8580778, 2) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCN(CC1)C1CCC1)-n1ccnn1 Show InChI InChI=1S/C17H21N9O/c27-17-14(25-5-4-20-22-25)11-21-26(17)16-10-15(18-12-19-16)24-8-6-23(7-9-24)13-2-1-3-13/h4-5,10-13,21H,1-3,6-9H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...				US Patent US8580778 (2013) BindingDB Entry DOI: 10.7270/Q21C1VH5
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3623 (US8524699, 28) Show SMILES COCCN1CCN(CC1)c1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C19H23N7O2/c1-28-10-9-24-5-7-25(8-6-24)17-11-18(22-14-21-17)26-19(27)16(13-23-26)15-3-2-4-20-12-15/h2-4,11-14,23H,5-10H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	890	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3629 (US8524699, 46) Show SMILES O=c1c(c[nH]n1-c1cnccn1)-c1cccnc1 Show InChI InChI=1S/C12H9N5O/c18-12-10(9-2-1-3-13-6-9)7-16-17(12)11-8-14-4-5-15-11/h1-8,16H	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118337 (US8653111, 61) Show SMILES Cc1cc(ncc1Br)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H9BrN6O/c1-7-4-10(13-5-8(7)12)18-11(19)9(6-15-18)17-3-2-14-16-17/h2-6,15H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3643 (US8524699, 44) Show SMILES O=c1c(c[nH]n1-c1cc(ncn1)N1CCCCC1)-c1cncc(c1)C#N Show InChI InChI=1S/C18H17N7O/c19-8-13-6-14(10-20-9-13)15-11-23-25(18(15)26)17-7-16(21-12-22-17)24-4-2-1-3-5-24/h6-7,9-12,23H,1-5H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118334 (US8653111, 50) Show SMILES Cc1cc(on1)-c1c[nH]n(-c2ccccn2)c1=O Show InChI InChI=1S/C12H10N4O2/c1-8-6-10(18-15-8)9-7-14-16(12(9)17)11-4-2-3-5-13-11/h2-7,14H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118336 (US8653111, 60) Show SMILES CCc1cc(ncn1)-n1[nH]cc(-n2cnc(c2)C(F)(F)F)c1=O Show InChI InChI=1S/C13H11F3N6O/c1-2-8-3-11(18-6-17-8)22-12(23)9(4-20-22)21-5-10(19-7-21)13(14,15)16/h3-7,20H,2H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3644 (US8524699, 55) Show SMILES CCN(CC)CCCCCCNc1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C22H31N7O/c1-3-28(4-2)13-8-6-5-7-12-24-20-14-21(26-17-25-20)29-22(30)19(16-27-29)18-10-9-11-23-15-18/h9-11,14-17,27H,3-8,12-13H2,1-2H3,(H,24,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118343 (US8653111, 101) Show SMILES OC1CN(C1)c1cc(ncn1)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C13H13N7O2/c21-9-5-19(6-9)11-3-12(16-7-15-11)20-13(22)10(4-17-20)18-2-1-14-8-18/h1-4,7-9,17,21H,5-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118332 (US8653111, 43) Show SMILES Cc1cn(nn1)-c1c[nH]n(-c2cnccn2)c1=O Show InChI InChI=1S/C10H9N7O/c1-7-6-16(15-14-7)8-4-13-17(10(8)18)9-5-11-2-3-12-9/h2-6,13H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118340 (US8653111, 83) Show SMILES FC(F)(F)c1ccnc(c1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C11H7F3N6O/c12-11(13,14)7-1-2-15-9(5-7)20-10(21)8(6-17-20)19-4-3-16-18-19/h1-6,17H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118335 (US8653111, 55) Show SMILES Cc1cn(cn1)-c1c[nH]n(-c2ccccn2)c1=O Show InChI InChI=1S/C12H11N5O/c1-9-7-16(8-14-9)10-6-15-17(12(10)18)11-4-2-3-5-13-11/h2-8,15H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3698 (US8524699, 22) Show SMILES O=c1c(c[nH]n1-c1ccc(nn1)-c1ccccc1)-c1cccnc1 Show InChI InChI=1S/C18H13N5O/c24-18-15(14-7-4-10-19-11-14)12-20-23(18)17-9-8-16(21-22-17)13-5-2-1-3-6-13/h1-12,20H	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3723 (US8524699, 6) Show SMILES O=c1c(c[nH]n1-c1nc2ccccc2s1)-c1cccnc1 Show InChI InChI=1S/C15H10N4OS/c20-14-11(10-4-3-7-16-8-10)9-17-19(14)15-18-12-5-1-2-6-13(12)21-15/h1-9,17H	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM118342 (US8653111, 91) Show SMILES Cc1cnc(cc1C)-n1[nH]cc(-n2ccnc2)c1=O Show InChI InChI=1S/C13H13N5O/c1-9-5-12(15-6-10(9)2)18-13(19)11(7-16-18)17-4-3-14-8-17/h3-8,16H,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...				US Patent US8653111 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GMD
					More data for this Ligand-Target Pair
Transmembrane prolyl 4-hydroxylase (Homo sapiens (Human))	BDBM3734 (US8524699, 26) Show SMILES CN(C)CCOc1cc(ncn1)-n1[nH]cc(-c2cccnc2)c1=O Show InChI InChI=1S/C16H18N6O2/c1-21(2)6-7-24-15-8-14(18-11-19-15)22-16(23)13(10-20-22)12-4-3-5-17-9-12/h3-5,8-11,20H,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	7.5	25
Bayer Intellectual Property GmbH US Patent					Assay Description In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.				US Patent US8524699 (2013) BindingDB Entry DOI: 10.7270/Q2TB15J4
					More data for this Ligand-Target Pair