Reaction Details |
| Report a problem with these data |
Target | Cathepsin B |
---|
Ligand | BDBM110192 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Cathepsin B Inhibition Assay |
---|
pH | 5.5±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 4.947e+4± 164 nM |
---|
Comments | extracted |
---|
Citation | Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cathepsin B |
---|
Name: | Cathepsin B |
Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
Type: | Enzyme |
Mol. Mass.: | 37819.69 |
Organism: | Homo sapiens (Human) |
Description: | gi_63102437 |
Residue: | 339 |
Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
BDBM110192 |
---|
n/a |
---|
Name | BDBM110192 |
Synonyms: | 3-(2,4-Dihydroxyphenyl)-1-(furan-2-yl)propenone (14) |
Type | Small organic molecule |
Emp. Form. | C13H10O4 |
Mol. Mass. | 230.2161 |
SMILES | Oc1ccc(\C=C\C(=O)c2ccco2)c(O)c1 |
Structure |
|